COMU is a highly efficient coupling reagent that produces yields as good as or better than HATU. The dimethylmorpholino skeleton in COMU affords high solubility in DMF, permitting solutions to be prepared that are approximately four times as concentrated as HBTU or HATU solutions. In contrast to HATU, HBTU and HCTU, COMU only requires one equivalent of base in coupling reactions (A El-Faham, RS Funosas, R Prohens, F Albericio, Chem. Eur. J., 2009, 15, 9404-16). It produces very low racemization and is a preferred reagent for fragment coupling. COMU with DMP (2,6-dimethylpyridine) can couple easily racemized phenylglycine derivatives with >97% retention of configuration. (C. Liang, M.A.M. Behnam, T.R. Suderman, C.D. Klein, Tetrahedron Lett., 2017, 58, 2325-9.) COMU is also effective in microwave-heated reactions.COMU couplings can be monitored by a color change of the solution. The coupling reaction byproducts are water-soluble, thus enabling easier workup of solution-phase acylations.Molecular Weight: 428.27
